Functional Genomics
Group
Our group focuses on the system biology and
synthetic biology underlying the biological processes that convert light and CO2
to biofuels. First, using the oleaginous microalgae Nannochloropsis spp. as the model
system in photosynthetic biofuels, we dissect the genetic basis, evolution, and
regulatory network of energy aglae, and construct genetically engineered Nannochloropsis with high carbon fixation rate and
oil productivity. Second, we used Clostridium spp. as a
model in cellulosic biofuels to study the mechanisms of biological cellulose
conversion and to design artificial cells with high cellulose degradation efficiency.
Third, with our collaborators across the globe, we are developing and applying single-cell
sorting and sequencing technologies on key areas such as soil metabolism, ocean
carbon sink and human microbiota. These efforts are allowing us to develop and validate
the theory of Single-cell Bioprocess Engineering.
